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error-related functional connectivity of the habenula in humans Aurora, West Virginia

Two subjects had more than one-third missing data on over one-third of trials and were removed from the analysis. Brain Mapp. 2, 189–21010.1002/hbm.460020402 [Cross Ref]Friston K. Our findings of Hbconnectivity with salience network regions may indicatethat the Hb also plays a role in this critical circuit.Finally, several regions for which we detected significantpositive connectivity with the Hb CrossRefMedlineWeb of ScienceGoogle Scholar ↵ Nachev P, Rees G, Parton A, Kennard C, Husain M .

They were drug-free while staying in an inpatient treatment unit prior to the current fMRI study. Midbrain dopamine neurons respond to both unpredicted rewarding stimuli and to cues previously paired with rewards (1), consistent with behavioral approach toward those cues. designed research; R.P.L. The task is presented in Fig. 1A.

Curr Biol 2005;15:122-128. D., Holmes A. Similarly,we observed some overlap in connectivity of the Hb anddorsomedial thalamus with the VTA and pons, a findingthat is consistent with the known anatomy of the dorsome-dial thalamus, which receives projections Habenula Responses to Negative CS Value.

Hum. Neuroimage 2009;47:1408-1416. Hum Brain Mapp 2009;30:3772-3782. Collectively, these data suggest dissociable effects of acute cocaine on non-drug reward processes, with cocaine consumption partially ameliorating dependence-related insensitivity to reinforcing outcomes/‘liking’, but having no discernible effect on dependence-related alterations

Here, by using high-resolution fMRI, in conjunction with computational modeling of reinforcement learning in a paradigm that included primary punishments (painful electric shocks), we were able to test directly whether the Published online before print July 28, 2014, doi: 10.1073/pnas.1323586111 PNAS August 12, 2014 vol. 111 no. 32 11858-11863 Classifications Biological Sciences Neuroscience Open Access Access OA Abstract » Full Text (HTML) Full Our dataextend these prior findings, indicating that stronger Hbconnectivity with default mode network regions andweaker connectivity with salience network areas is associ-ated with depressed mood.Differential Functional Connectivity of theHabenula and ThalamusAs Exp.

Standard image preprocessing was performed. Reviewing 38 fMRI studies of preresponse conflict, decision uncertainty, response errors, and negative feedback, Ridderinkhof et al. (2004) showed that the anterior and posterior preSMA is each more associated with decision This approach enables us to be confident that the signals we identified emanate from the habenula and not the neighboring MD thalamus. Neurosci. 28, 11825–1182910.1523/JNEUROSCI.3463-08.2008 [PMC free article] [PubMed] [Cross Ref]Holroyd C., Coles M.

There were two trial types: “go” and “stop,” randomly intermixed. Fundamental role for lateral habenula in promoting subjective decision biases. In particular, the boundary between SMA and posterior preSMA (H4–H5 and L5–L6) remained unchanged across these solution metrics. Taken together, these findings suggested that the functions of the anterior and posterior parts of the preSMA could be further delineated.

Statistical tests conducted on these parametric contrast estimates at the group level indicate the reliability (across subjects) of the regression coefficient relating continuously varying CS value to habenula response at the Nevertheless, we reran all the analyses using the data smoothed with a 4-mm Gaussian kernel and those seeds with 4-mm radius. A midline dissociation between error-processing and response-conflict monitoring. Lia, b, ca Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06519, USAb Inter-departmental Neuroscience Program, Yale University, New Haven, CT 06520, USAc Department of Neurobiology, Yale University

CrossRefMedlineWeb of ScienceGoogle Scholar ↵ Raghunathan TE, Rosenthal R, Rubin DB (1996) Comparing correlated but nonoverlapping correlations. Otherwise, non-stationary time courses are known to produce spurious regression results (Granger and Newbold, 2001). The substantia nigra is the main output of the LHb (5) and plays a crucial role in associative learning. Indeed, Ji and Shepard (2007) and Hikosaka et al. (2008) showed that neurons in the LH might exert inhibitory effects on neurons in the VTA/SN by exciting local GABAergic neurons.

J., Barrot M. (2009). The HCP further performedhighpass filtering (cutoff 5 2,000s) and denoising ofresting-state functional runs through the FMRIB SoftwareLibrary (FSL) ICA-FIX algorithm [Griffanti et al., 2014;Smith et al., 2004]. L., Yang W., Liang H. (2000). CrossRefMedlineWeb of ScienceGoogle Scholar ↵ Tanji J .

Activation in the VTA and nucleus accumbens increases in anticipation of both gains and losses. The latter result thus needs to be reconciled with findings from single-unit recordings of monkeys showing habenula-projecting neurons in the GPi (Hong and Hikosaka, 2008).Methodological considerationsSome methodological issues need to be Neuron 60, 720–72910.1016/j.neuron.2008.09.035 [PMC free article] [PubMed] [Cross Ref]Hutton C., Bork A., Josephs O., Deichmann R., Ashburner J., Turner R. (2002). Previous SectionNext Section Results Behavioral Performance.

Neuropsychopharmacology 35(1):4–26. In: Dwivedi, Y, editor. The Human Investigation Committee at Yale University School of Medicine approved the study, and all subjects signed an informed consent prior to participation. Abstract/FREE Full Text « Previous | Next Article » Table of Contents This Article Cereb.

D. (2007). Psychol Methods 1(2):178–183. These regions included a cluster in the VTA/substantia nigra (SN), internal segment of globus pallidus, bilateral amygdala, and insula. The margin of the brain at x = 0 was first traced on the standard 152 brain MNI template of SPM8 and fitted with a quadratic function of z and y

During fMRI, subjects (n = 23) performed a Pavlovian conditioning task in which they were passively exposed to seven abstract images [conditioned stimuli (CSs)] that were followed by different reinforcing outcomes doi: 10.3389/fnhum.2011.00025. Subject demographicsMeasure All subjectsHigh subclinicaldepression groupLow subclinicaldepression groupAge (Years 6 SD) 28.9 6 3.0 28.4 6 3.0 29.4 6 2.9Sex (F/M) 30/20 13/12 17/8Handedness (R/L) 46/4 23/2 23/2Education (Years 6 SD) With resampling, we produced surrogate data by randomly generating time series with the same mean, variance, autocorrelation function, and spectrum as the original data (Theiler et al., 1992), as implemented in

The impact of prior risk experiences on subsequent risky decision-making: the role of the insula. In 59 adults performing a stop signal task during functional magnetic resonance imaging (fMRI), we identified brain regions showing greater psychophysiological interaction with the habenula during stop error as compared to Nat Rev Neurosci 2007;8:700-711. CrossRefMedlineWeb of ScienceGoogle Scholar ↵ Friston KJ, et al. (1997) Psychophysiological and modulatory interactions in neuroimaging.

Frequencies contributing to functional connectivity in the cerebral cortex in “resting-state” data. Because of their small size and hence intersubject variability, it would be much harder to obtain significant patterns of functional connectivity across a population of subjects. CrossRefMedlineWeb of ScienceGoogle Scholar ↵ Salas R, Baldwin P, de Biasi M, Montague PR (2010) BOLD Responses to Negative Reward Prediction Errors in Human Habenula.