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fingerstick triglyceride lab error Maybrook, New York

Post Forum Badge Post Forum members consistently offer thought-provoking, timely comments on politics, national and international affairs. Specificity to classify participants as meeting clinical guidelines was ≥ 78% for all categories of lipids, 95% for hsCRP ≥ 1 mg/L, and 99% for hsCRP ≥ 3 mg/L but <10 Plasma flowing to the left side of the cassette moves through a region containing dextran sulfate and magnesium acetate, which precipitates apolipoprotein B-containing lipoproteins. Differences between the laboratory and PLA values, however, were not significant (P = 0.946) (8)(16)(17).

The body stores calories that it doesn’t use right away as triglycerides. These triglycerides circulate in the blood to provide energy for your muscles to work. Bivariate scatterplots with regression lines (thick solid line) and 95% confidence intervals (thin solid lines) for the mean for laboratory and PLA values.(A), total cholesterol. Bias = 0.192 − 0.080(portable LDL-C); r = 0.14; Sy|x = 0.168; mean bias, 0.043 g/L; 2 SD = 0.338 g/L; P = 0.046. (E), calculated non-HDL cholesterol.

Although the SD of the bias was large (0.188 g/L, or 6.9% of the mean total cholesterol concentration) and the bias was slightly concentration dependent (bias slope, −0.075), the differences between Indeed, the variability of the PLA method, reflected in the slopes of the regression lines and the SDs of the biases between the PLA and laboratory, were very high and in ATP III guidelines1 were used to define abnormal serum cholesterol values: (1) TC ≥ 200 mg/dL, (2) TG ≥ 150 mg/dL, (3) HDL-C < 40 mg/dL, (4) LDL-C ≥ 130 mg/dL Non-HDL cholesterol calculations using lipid values from both methods correlated strongly but with a large intercept (r = 0.88; y-intercept, 0.417 g/L; slope, 0.813; Sy|x = 0.172; Table 1 ⇑ and

Equation for line: Portable triglycerides = 0.329 + 0.979(laboratory triglycerides); r = 0.97; Sy|x = 0.148. (D), calculated LDL-C. Statistical analysis was performed using SAS statistical software version 9.1 (SAS Institute, Inc., Cary, NC).9ResultsParticipants had a mean [standard deviation] age of 48.0 [±13.5]; 66% were female; and 36% were nonwhite These results may not be generalizable to patients at high risk for CVD or who have known hyperlipidemia.Keywords: CVD Prevention, CVD Screening, Fingerstick Technology, Hypercholesterolemia, C-Reactive Protein, Lipid Measurement. statistics All lipid values were described as the mean ± SD and range.

This difference is usually <0.100 g/L within the range of triglyceride concentrations measured in patients in this study. Use of the total cholesterol and non-HDL cholesterol values obtained from PLAs warrants further investigation in larger trials. Lipid screening based on both total cholesterol and non-HDL cholesterol may be useful, but their individual components appear to be too inaccurate to be used for clinical risk assessment, initiation of Please update your browser permissions to allow them.

Facebook Twitter Reddit StumbleUpon Digg Delicious Most Read 1 NFL ratings plunge could spell doom for traditional TV 2 Donald Trump isn't going to like this new report about his campaign's We appreciate your helpful feedback! Accordingly, the (laboratory − CDC) intercept and slope were much smaller than the analogous (PLA − laboratory) values. Generated Fri, 14 Oct 2016 07:01:32 GMT by s_ac4 (squid/3.5.20) ERROR The requested URL could not be retrieved The following error was encountered while trying to retrieve the URL: Connection

Equation for line: Portable cholesterol = 0.463 + 0.836(laboratory cholesterol); r = 0.88; Sy|x = 0.178. (B), HDL-C. Agreement between lipid values obtained from the laboratory and the PLA were described as the mean bias (laboratory value minus PLA value) ± SD. We cannot draw conclusions regarding the clinical utility for use in ongoing management and treatment decisions.Future investigations for the role of fingerstick analysis include how well screening improves serum lipid control e69–e171.

Portable measurements of triglycerides and HDL-C were overestimated systematically, and LDL-C was underestimated. He noted that a fingerstick blood draw, a key part of the early marketing of Theranos's service, is notoriously difficult to do well. All participants signed written informed consent.MeasuresAt the baseline study visit, all participants underwent concurrent fasting capillary blood sampling obtained by fingerstick and venous blood draw. Potential participants were excluded if they had end-stage renal disease, liver disease, or known or suspected malignancy with a life expectancy less than 5 years.

In general, PLAs are accurate, with biases and coefficients of analytical variation that meet the National Cholesterol Education Program (NCEP) Lipid Standardization Panel guidelines for acceptable total cholesterol measurement (total analytic Even if you don’t lose weight, exercise can help control your triglyceride level. The other two companies whose services were used in the study responded to the study less critically than Theranos. "When you cut through all the data, the study points out a Dudley added that if Theranos' results can be thrown off by such factors, it should be disclosed.

EinersonFind this author on Google ScholarFind this author on PubMedSearch for this author on this sitePatrick E. A portable machine can also perform this test. You should also avoid alcohol for 24 hours before the test. Retrieved from Triglycerides. (2015, October).

The sensitivity of categorizing patients with hsCRP ≥ 1 mg/L was 75% but was less sensitive for hsCRP ≥ 3 mg/L but <10 mg/L. Horizontal lines were drawn from the ordinate values representing the mean bias and the mean bias ± 2 SD (15). Immediately afterward, venous samples were obtained from an antecubital vein with a tourniquet time of <2 min and dispensed into evacuated red-top glass collection tubes (Vacutainer; Becton Dickinson). We'll share your response with our medical review team, who will update any incorrect information in the article.

Privacy policy We’re unable to offer personal health advice, but we’ve partnered with trusted telehealth provider Amwell, who can connect you with a doctor. Diets high in carbohydrates, especially sugar, can increase triglycerides. Each analyte showed close agreement with the confirmatory values except for a slight but consistent underestimation of triglyceride values. LDL-C was estimated using the Friedewald formula (12).

Clin Chem 1993;39:271-277.OpenUrlAbstract/FREE Full Text ↵ Executive summary of the third report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in This value was exceeded by 15 (23.8%) of the PLA HDL-C values, including 10 overestimations and 5 underestimations of laboratory HDL-C values. Retrieved May 25, 2012, from Triglycerides. (2012, January 20). Accordingly, for calculated LDL-C, the (laboratory − CDC) intercept and slope were much smaller than analogous (PLA − laboratory) values.

The most significant source of differences between techniques is the laboratory’s triglycerides assay, which accounts for the presence of free glycerol by a blanking technique. They’ll press against the puncture site with a cotton ball or gauze to stop any bleeding. Clin Chem 1996;42:2002-2007.OpenUrlAbstract/FREE Full Text ↵ Rogers EJ, Misner L, Ockene IS, Nicolosi RJ. Last year, he sent some medical students to use Theranos's technology and compare it with lab results, finding discrepancies -- especially among potassium levels.

We thank Lisa Rehm for her editorial assistance.References1. This is an important distinction because individual laboratory values and their trends dictate patient diagnosis and treatment algorithms (8). Please try the request again. Baseline data collection was conducted between January 2005 and June 2007.

Lab Tests Online. The PLA bias remained small (−0.012 g/L) after accounting for the small (0.003 g/L) non-concentration-dependent laboratory bias identified in proficiency testing. Studies show that carbohydrates play an important role in controlling triglyceride level. Reflotron performance in a community screening program: results of the Massachusetts model systems for blood cholesterol screening project.

There are many reasons why your triglyceride level may be high. Author manuscript; available in PMC 2009 Sep 24.Published in final edited form as:Am J Health Promot. 2009 Mar–Apr; 23(4): 279–282. It's possible, he said, that Theranos's results are the more accurate, correct ones. "What they’re trying to do is suggest that Theranos's results are less accurate or less reliable, but this If you have prediabetes or diabetes, it’s important to monitor your triglyceride level regularly because triglycerides will increase when you aren’t properly maintaining your blood sugar levels.

In our laboratory, this technique has a CV of 2–3%. Louis, MO. . Spam Offensive Disagree Off-Topic Among the criteria for featured comments: likes by users, replies by users, previous history of valuable commenting, and selection by moderators.