PMC1380484. Journal of the Royal Statistical Society Series B 57, 289–300. If that wasn't sound a statistician should wish to die young or quit profession soon, in order to escape multiplying type I error in his life course. –ttnphns Dec 19 '11 when m 0 = m {\displaystyle m_{0}=m} so the global null hypothesis is true).[citation needed] A procedure controls the FWER in the strong sense if the FWER control at level α

no alpha-cummulation) if adjustments for multiple comparisons are applied. Using a statistical test, we reject the null hypothesis if the test is declared significant. Next, we transform the data to get each simulation in a row (section 1.5.4). (The data output from proc multtest has nsims*ntests rows. ISBN0-471-55761-7. ^ Romano, J.P.; Wolf, M. (2005a). "Exact and approximate stepdown methods for multiple hypothesis testing".

Note that these methods require only the p-values to adjust and the number of p-values that are being compared. This is different from methods such as Tukey or Dunnett that require P. (1995). "Multiple hypothesis testing". Accounting for the dependence structure of the p-values (or of the individual test statistics) produces more powerful procedures. Please try the request again.

n number of comparisons, must be at least length(p); only set this (to non-default) when you know what you are doing! raw p-values for a series of 25 p-values. The dashed line represents a one-to-one line. # # # Multiple comparisons example with five p-values ### -------------------------------------------------------------- ### New York: Wiley. Please try the request again.

Essentially, this is achieved by accommodating a `worst-case' dependence structure (which is close to independence for most practical purposes). New York: John Wiley. The control of the false discovery rate in multiple testing under dependency. Retrieved from "https://en.wikipedia.org/w/index.php?title=Family-wise_error_rate&oldid=742737402" Categories: Hypothesis testingMultiple comparisonsRatesHidden categories: Articles needing additional references from June 2016All articles needing additional referencesAll articles with unsourced statementsArticles with unsourced statements from June 2016Wikipedia articles needing

In this post we'll develop a simulation to explore the impact of "strong" and "weak" control of the family-wise error rate offered in multiple comparison corrections. You can help by adding to it. (February 2013) Resampling procedures[edit] The procedures of Bonferroni and Holm control the FWER under any dependence structure of the p-values (or equivalently the individual Jobs for R usersData Science Consultant @ Notre Dame, Indiana, United StatesFinance Manager @ Seattle, U.S.Data Scientist – AnalyticsTransportation Market Research Analyst @ Arlington, U.S.Data AnalystData Scientist for Madlan @ Tel P. (1995). "Multiple hypothesis testing".

asked 3 years ago viewed 326 times active 2 years ago Related 0Help with Johansen procedure to check the cointegration11What is the correct procedure to choose the lag when performing Johansen Epidemiology.1990;1(1):43-6. Is powered by WordPress using a bavotasan.com design. doi:10.1111/j.1468-0262.2005.00615.x. ^ Shaffer, J.

First we'll recode the rejections (assuming a 0.05 alpha level) so that non-rejections are 0 and rejections are 1/number of tests. What´s wrong with Bonferroni adjustments. Journal of the American Statistical Association. 100: 94–108. Is it OK for graduate students to draft the research proposal for their advisor’s funding application (like NIH’s or NSF’s grant application)?

With the data created, we can use proc multtest to apply the FDR procedure, with the ODS system saving the results. The Bonferroni correction is often considered as merely controlling the FWER, but in fact also controls the per-family error rate.[8] References[edit] ^ Hochberg, Y.; Tamhane, A. Please try the request again. To get some sense of how conservative these different adjustments are, see the two plots below in this chapter.

From my point of view 1), 2), 3) together just mirror, how carefully we must the "whole theory breaks" criterion. Summing the test results over Hi will give us the following table and related random variables: Null hypothesis is true (H0) Alternative hypothesis is true (HA) Total Test is declared significant This procedure is more powerful than Bonferroni but the gain is small. Because FWER control is concerned with at least one false discovery, unlike per-family error rate control it does not treat multiple simultaneous false discoveries as any worse than one false discovery.

ISBN0-471-82222-1. ^ Aickin, M; Gensler, H (1996). "Adjusting for multiple testing when reporting research results: the Bonferroni vs Holm methods". Biometrics 48, 1005–1013. (Explains the adjusted P-value approach.) See Also pairwise.* functions such as pairwise.t.test. FWER control limits the probability of at least one false discovery, whereas FDR control limits (in a loose sense) the expected proportion of false discoveries. Should all members of a family have the same response variable?

Suppose we have a number m of multiple null hypotheses, denoted by: H1,H2,...,Hm. But such an approach is conservative if dependence is actually positive. Your cache administrator is webmaster. Then we sum across the simulations with another call to apply() and show the results with a simple table.

For the most part, we feel more comfortable using multiple testing procedures with "strong control". Holm, S. (1979). share|improve this answer answered Dec 9 '11 at 6:54 gung 74.1k19160309 add a comment| up vote 3 down vote The criterion is that the hypotheses are interdependent in the sense that For our simulation, we'll develop flexible code to generate some p-values from false nulls and others from true nulls.

However, both 1) and 2) oppose, that the general null hypothesis is rarely fully used in the process of scientific research - so the "whole theory breaks" criterion does not automatically Journal of Modern Applied Statistical Methods. 14 (1): 12–23. Annual Review of Psychology 46, 561–576. (An excellent review of the area.) Sarkar, S. (1998). References Benjamini, Y., and Hochberg, Y. (1995).