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DNA polymerase ζ and the control of DNA damage induced mutagenesis in eukaryotes. Biochem. 71, 133–163.CrossRefPubMedGoogle Scholar2.Friedberg E.C., Wagner R., Radman M. 2002. Articles by Bailey, L. Autonomous 3′ → 5′ exonucleases can proofread for DNA polymerase β from rat liver.

FOOTNOTES Received 31 December 2002. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work You must disable the application while logging in or check with your system administrator. Biokhim.

Rafa_el 8,765 views 1:55 Loading more suggestions... Biologocal asymmetries and the fidelity of eukaryotic DNA replication. Instead, Pol I starts adding nucleotides at the RNA primer:template junction known as the origin of replication (ori). Antimutagenic role of autonomous 3′ → 5′ exonucleases.

A full length cDNA of hREV3 is predicted to encode DNA polymerase ζ for damage-induced mutagenesis in humans. Cell. 59 (2): 163–175. Genes Dev. 17, 2777–2785.CrossRefPubMedGoogle Scholar67.Bebenek K., Matsuda T., Matsutani C., et al. 2001. Biol.

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doi:10.1038/cr.2007.117. Close Yeah, keep it Undo Close This video is unavailable. Cooperation of the terminal deoxynucleotydil transferase with DNA polymerase α in the replication of ultraviolet-irradiated DNA. Genes Dev. 14, 1642–1650.PubMedGoogle Scholar42.Zhang Y., Yuan F., Wu X., et al. 2001.

doi:10.1093/nar/gkr1102. This results in elongation of the newly forming strand in a 5'-3' direction. Sign in to make your opinion count. J.

Mol. Zh. Nature. 399, 700–704.PubMedGoogle Scholar28.Matsuda T., Bebenek K., Matsutani C., et al. 2000. Eukaryotic DNA polymerases: Proposal for a revised nomenclature.

In general, only the information that you provide, or the choices you make while visiting a web site, can be stored in a cookie. Mol. Replication across O6-methylguanine by human DNA polymerase β in vitro. Life Sci. 68 (2): 219–33.

Evol. More information Accept Over 10 million scientific documents at your fingertips Switch Edition Academic Edition Corporate Edition Home Impressum Legal Information Contact Us © 2016 Springer International Publishing. Localization of DNA polymerases η and ι to the replication machinery is tightly coordinated in human cells. J.

We find that PrimPol is a mutagenic polymerase, with a unique error specificity that is highly biased towards insertion-deletion errors. Enzymatic and structural mechanisms of DNA repair in isolated mammalian chromatin. PMID13563462. ^ Richardson, C.C.; Schildkraut, C.L.; Aposhian, H.V.; Kornberg, A. (1964). "Enzymatic synthesis of deoxyribonucleic acid. Chem. 276, 2317–2320.PubMedGoogle Scholar68.Shevelev I.V., Belyakova N.V., Kravetskaya T.P., Krutyakov V.M. 2000.

Pol α complex (pol α-DNA primase complex) consists of four subunits: the catalytic subunit POLA1, the regulatory subunit POLA2, and the small and the large primase subunits PRIM1 and PRIM2 respectively. Eukaryotic DNA polymerases. During SOS induction, Pol IV production is increased tenfold and one of the functions during this time is to interfere with Pol III holoenzyme processivity. Res. 459, 237–242.PubMedGoogle Scholar69.Ronzhina N.L., Kravetskaya T.P., Krutyakov V.M. 2000.

Deoxy-ribonucleic acid polymerase in spores of Bacillus subtilis". The C-terminus region is thought to provide a checkpoint before entering anaphase, provide stability to the holoenzyme, and add proteins to the holoenzyme necessary for initiation of replication.[29] Polymerases η, ι PMID13747134. ^ Zimmerman, B.K. (1966). "Purification and properties of deoxyribonucleic acid polymerase from Micrococcus lysodeikticus". Working...

Response of human DNA polymerase ι to DNA lesions. Arch. These highly processive complexes show a greater affinity to correct primers than specialized DNA polymerases do. Oncol. 18, 97–103.PubMedGoogle Scholar27.Masutani C., Kusumoto R., Yamada A. 1999.

Among tandem mutations that occur simultaneously at adjacent sites, we find an especially skewed distribution of ancestral and derived dinucleotides, with $\textrm{GC}\to \textrm{AA}$, $\textrm{GA}\to \textrm{TT}$ and their reverse complements making up Gefter in 1970 while further elucidating the role of Pol I in E. Sci. Online ISSN 1362-4962 - Print ISSN 0305-1048 Copyright ©  2016 Oxford University Press Oxford Journals Oxford University Press Site Map Privacy Policy Cookie Policy Legal Notices Frequently Asked Questions Other Oxford University

Proc. Chem. 277, 18 454–18 458.CrossRefGoogle Scholar50.Ramadan K., Shevelev I.V., Maga G., Hubscher U. 2004. Natl. doi:10.1016/j.molcel.2015.05.038.

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